学术简历

2016-至今，预聘制助理教授，长聘副教授，教授，澳门新甫京娱乐娱城平台

2016-至今，中心研究员，北大-清华生命联合中心

2022-至今，领衔科学家，昌平实验室

2014–2016，博士后研究员，美国国立卫生研究院

2010–2014，博士，交叉学科博士培养项目，英属哥伦比亚大学化学系、TRIUMF原子能国家实验室、英属哥伦比亚癌症中心

2006–2010，理学学士，南京大学化学化工学院化学系

 

研究领域

研究兴趣集中在发展放射化学工具解决临床问题和能源环境难题，具体研究方向如下：

1）放射性药物化学：新靶点、新平台技术、新螯合剂；

2）放射性同位素生产、纯化与应用；

3）放疗响应药物及中子俘获治疗药物；

4）核辐射驱动的惰性物质活化与转化。

 

获奖经历

2025.04 中关村论坛重大成果，科技部、国家发展改革委、国务院国资委、中国科学院、中国工程院、中国科协和北京市政府

2025.03 勃林格殷格翰研究员奖 (Faculty Research Awardee，Boehringer Ingelheim)

2024.11 九三学社首届科技创新青年英才

2024.08 科学探索奖，新基石科学基金会

2024.04 拜耳学者奖，Bayer Healthcare Co. Ltd.

2023.09 澳门新甫京娱乐娱城平台研究生教学优秀奖

2022.09 国家青年科学基金（A类），国家自然科学基金委

2021.07 入选SNMMI“Ones to Watch” for 2021, 美国核医学与分子影像学会

2021.04 中国化学会青年化学奖

2019.12 药明康德生命化学青年学者奖

2019.12 学院青年教师教学基本功大赛一等奖

2018.11 Fairchild Award, 18^th International Congress of Neutron Capture Therapy

2018.11 澳门新甫京娱乐娱城平台绿叶生物青年科学家奖

2016.06 Distinguished Scientist Award, NIH-CSSA Committee

2015.06 Michael J. Welch Postdoctoral Award, Society of Nuclear Medicine and Molecular Imaging

2015.06 JNM Editor’s Choice Award, Society of Nuclear Medicine and Molecular Imaging

2015.04 Alavi-Mandell Award, Society of Nuclear Medicine and Molecular Imaging

2014.08 Edward Piers Memorial Award, Edward Piers Foundation

2014.06 Chinese Government Award for Outstanding Abroad Students, China Scholarship Council

2013.06 Young Investigator Award, 37^th CASNMMIg

2013.02 Boehringer Ingelheim Scholarship, Boehringer Ingelheim Foundation

2006.01 Silver Medal, 21^th Chinese Chemistry Olympiad

 

代表性文章

1. Xi-Yang Cui#, Zhu Li#, Ziren Kong#, Yu Liu, Hao Meng, Zihao Wen, Changlun Wang, Junyi Chen, Mengxin Xu, Yiyan Li, Jingyue Gao, Wenjia Zhu, Zhixin Hao, Li Huo, Shaoyan Liu, Zhi Yang, Zhibo Liu*. Covalent Targeted Radioligands Potentiate Radionuclide Therapy. Nature. 2024, 630: 206–213.
2. Qinyang Wang^#, Yupeng Wang^#, Jingjin Ding, Chunhong Wang, Xuehan Zhou, Wenqing Gao, Huanwei Huang, Feng Shao*, Zhibo Liu*, A Bioorthogonal System Reveals Antitumour Immune Function of Pyroptosis. Nature, 2020, 579, 421–426
3. Qunfeng Fu#, Zhi Gu#, Siyong Shen#, Yifei Bai, Xianglin Wang, Mengxin Xu, Pengwei Sun, Junyi Chen, Dongxuan Li, Zhibo Liu*. Radiotherapy Activates Picolinium Prodrugs in Tumors. Nat Chem.  2024, 16(8): 1348–1356.
4. Qunfeng Fu, Shuren Zhang, Siyong Shen, Zhi Gu, Junyi Chen,  Dongfan Song, Pengwei Sun, Chunhong Wang, Zhibin Guo, Yunlong Xiao, Yi Qin Gao, Zijian Guo*, Zhibo Liu*. Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours.  Nat Biomed Eng.  2024, 8: 1425–1435.
5. Ziren Kong#,Zhu Li#, XiYang Cui#, Wang Jian, Mengxin Xu, Yang Liu, Junyi Chen, Song Ni, Xiaowei Fan, Jiazhao Huang, Yansong Lin, Xinfeng Lin, Tianyu Men, Changming An, Nan Li, Chen Liu, Yi-Ming Zhu, Zhi Yang*, Zhibo Liu*, Shaoyan Liu*. CTR-FAPI PET enables precision management of medullary thyroid carcinoma. Cancer Discov. 2025, 15 (2): 316–328. 
6. Junyi Chen, Mengxin Xu, Zhu Li, Ziren Kong,  Jie Cai, Chunhong Wang, Bo-Shuai Mu, Xi-Yang Cui, Zizhu Zhang,  Tong Liu, Zhibo Liu*. A Bis-Boron Amino Acid for Positron Emission Tomography and Boron Neutron Capture Therapy. Angew Chem Int Ed. 2025, 64(1): e202413249. 
7. Mengqi Chen#, Chunhong Wang#, Xuanyu Wang, Zhiyu Tu, Zexuan Ding, Zhibo Liu*. An “AND” Logic-Gated Prodrug Micelle Locally Stimulates Antitumor Immunity. Adv Mater. 2024,  36(6): 2307818.
8.  Bo-Shuai Mu#, Yugang Zhang#, Mi Peng#, Zhiyu Tu, Zhenbo Guo, Siyong Shen, Yang Xu, Weiqiu Liang, Xianglin Wang, Meng Wang, Ding Ma*, Zhibo Liu*. Radiocatalytic Synthesis of Acetic Acid from CH₄ and CO₂. Angew Chem Int Ed. 2024, 63(44): e202407443.
9. Bo-Shuai Mu#, Yang Xu#, Zhiyu Tu, Weiqiu Liang, Jiahao Li, Xianglin Wang, Siyong Shen, Junyi Chen, Zhibo Liu*. Radiocatalytic ammonia synthesis from nitrogen and water. National Science Review. 2024, 11(11): nwae302.
10. Changlun Wang, Mengxin Xu, Zihang Zhang, Senhai Zeng, Siyong Shen, Zexuan Ding, Junyi Chen, Xi-Yang Cui, Zhibo Liu *. Locally unlocks prodrugs by radiopharmaceutical in tumor for cancer therapy. Science Bulletin. 2024, 69(17): 2745-2755.
11. Zhibin Guo, Xuanyu Wang, Yi Han, Siyong Shen, Peng Tian, Yuchen Hu, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Targeted Radionuclide Therapy Activates Prodrugs for Treating Metastasis. ACS Cent Sci. 2024, 10(12):2321-2330.
12. Zhu Li#, Junyi Chen#, Ziren Kong, Yixin Shi, Mengxin Xu, Bo-Shuai Mu, Nan Li, Wenbin Ma, Zhi Yang, Yu Wang*, Zhibo Liu*. A bis-boron boramino acid PET tracer for brain tumor diagnosis. Eur J Nucl Med Mol Imag. 2024, 51(6):1703-1712.
13. Qunfeng Fu#, Siyong Shen#, Pengwei Sun, Zhi Gu, Yifei Bai, Xianglin Wang, Zhibo Liu*. Bioorthogonal chemistry for prodrug activation in vivo. Chem Soc Rev. 2023, 52: 7737-7772.
14. Dongban Duan#, Yi Han#, Zhiyu Tu#, Haoxuan Guo, Zizhu Zhang, Yaxin Shi, Jiyuan Li, Qi Sun, Junyi Chen, Zhu Li, Tong Liu, Daqing Cui, Zhibo Liu*. Gadolinium Neutron Capture Reaction-Induced Nucleodynamic Therapy Potentiates Antitumor Immunity. CCS Chemistry. 2023, 5(11): 2589-2602.
15. Qiang Wei, Yuhxuan Lee, Weiqiu Liang, Xiaolei Chen, Bo-Shuai Mu, Xi-Yang Cui, Wangsuo Wu, Shuming Bai, Zhibo Liu*. Photocatalytic Direct Borylation of Carboxylic Acids. Nat Commun, 2022, 13, 7112.
16. Zhibin Guo^#, Hanyu Hong^#, Yuedan Zheng, Ziyang Wang, Zexuan Ding, Qunfeng Fu, Zhibo Liu*. Radiotherapy-Induced Cleavage of Quaternary Ammonium Groups Activates Prodrugs in Tumors. Angew Chem Int Ed, 2022, 61, e202205014.
17. Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu*. A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation. ACS Cent Sci, 2022, 8,837.
18. Zexuan Ding, Zhibin Guo, Yuedan Zheng, Ziyang Wang, Qunfeng Fu, Zhibo Liu*, Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors, J Am Chem Soc, 2022, 144, 9458.
19. Jiyuan Li^#, Qi Sun^#, Chuanjie Lu, Han Xiao, Zhibin Guo, Dongban Duan, Zizhu Zhang, Tong Liu, Zhibo Liu*, Boron Encapsulated In A Liposome Can Be Used for Combinational Neutron Capture Therapy. Nat Commun, 2022, 13, 2143.
20. Pu Zhang^#, Mengxin Xu^#, Jie Ding, Junyi Chen, Taiping Zhang, Li Huo*, Zhibo Liu*，Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy, Eur. J. Nucl. Med. Mol. Imaging, 2022, 49, 1985-1996.
21. Mengxin Xu^#, Pu Zhang^#, Jie Ding, Junyi Chen, Li Huo, Zhibo Liu*, Albumin Binder–Conjugated Fibroblast Activation Protein Inhibitor Radiopharmaceuticals for Cancer Therapy. J. Nucl. Med., 2022, 63, 952.
22. Zhu Li^#, Ziren Kong^#, Junyi Chen^#, Jiyuan Li, Nan Li, Zhi Yang*, Yu Wang*, Zhibo Liu*, ¹⁸F-Boramino Acid PET/CT in Healthy Volunteers and Glioma Patients, Eur. J. Nucl. Med. Mol. Imaging, 2021, 48, 3113–3121.
23. Ding, Yuchen Rui, Zi-Chen Li, Zhibo Liu*, Cationic Micelle as An In Vivo Catalyst for Tumour-Localized Cleavage Chemistry. Angew. Chem. Int. Ed., 2021, 133, 19903–19911.
24. Dongban Duan, Hao Dong, Zhiyu Tu, Chunhong Wang, Qunfeng Fu, Junyi Chen, Hai-peng Zhong, Ping Du, Ling-Dong Sun, Zhibo Liu*, Desilylation Induced by Metal Fluoride Nanocrystals Enables Cleavage Chemistry In Vivo. J. Am. Chem. Soc., 2021, 143, 2250–2255.
25. Qunfeng Fu, Hongyu Li, Dongban Duan, Changlun Wang, Huimin Ma, Zhibo Liu*, External Radiation–Induced Local Hydroxylation Enables Remote Release of Functional Molecules in Tumors, Angew. Chem. Int. Ed., 2020, 59, 21546-21552.