Abstract

We will discuss our recent work on engineering DNA probes to advance the performance and accessibility of spatial, single-cell, and single-molecule proteomics. Examples include scalable, high-plex sequential imaging methods using DNA barcoded probes and amplifiers, an in situ signal amplification method for enhancing the sensitivity of single-cell mass cytometry, and a separation-free immunoassay approaching single-molecule level sensitivity.

Biography

Peng Yin is a Professor of Systems Biology at Harvard Medical School, and a Core Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard University. He received a B.S. in Biochemistry and Molecular Biology and a Bachelor of Economics from Peking University, a M.S. in Molecular Pharmacology and a Ph.D. in Computer Science from Duke University, and finished postdoc training at Caltech. His lab focuses on developing and translating molecular technologies for life science research and medical applications.